Platelet-rich plasma (PRP) is derived from autologous blood, with platelets being the main constituent. PRP has high concentrations of growth factors including tissue growth factor and platelet-derived growth factors, which can medicate the proliferation of mesenchymal stem cells and increase matrix synthesis and collagen formation. PRP can reduce inflammation in an osteoarthritic joint by enhancing the expression of NF-Kappa-beta inhibitor, and thus reduce NF-kappa-beta signaling and dampen its downstream inflammatory cytokine activation.